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文章摘要
红细胞膜仿生氮化硼纳米球的制备及其作为抗肿瘤药物载体的研究
Erythrocyte membrane biomimetic boron nitride nanospheres as carrier for the delivery of antitumor drug
投稿时间:2017-11-30  修订日期:2017-12-08
DOI:
中文关键词: 氮化硼纳米球  红细胞膜  阿霉素  药物递送  癌症治疗
英文关键词: Boron nitride nanosphere  red blood cell membrane  doxorubicin  drug delivery  cancer therapy
基金项目:国家自然科学基金项目(面上项目,重点项目,重大项目)
作者单位E-mail
冯诗倪 江南大学 生物工程学院 fengshini1990@163.com 
张慧杰 江南大学 药学院  
高晓冬 江南大学 生物工程学院  
中西秀树 江南大学 生物工程学院 hideki@jiangnan.edu.cn 
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中文摘要:
      氮化硼纳米球作为一种新型纳米材料在生物医药领域的应用亟待探索。本文利用红细胞膜对BNNS进行包被,构建出新型仿生纳米给药系统RBC-BNNS。采用透射电镜(TEM)、粒径及电位分析等手段表征并对比了红细胞膜包被前后BNNS的基础性能。在此基础上,选用阿霉素作为抗癌药物模型,对比了细胞膜包被前后载体对阿霉素装载量的变化。选用HeLa细胞为肿瘤细胞模型,考察了RBC-BNNS的生物安全性以及DOX@RBC-BNNS的细胞摄取和体外抗肿瘤效果。本研究或可为癌症治疗药物输送体系的设计、构建提供有益的参考。
英文摘要:
      As a type of novel nanomaterials, the application of boron nitride nanospheres (BNNS) in biomedical field deserve deeply exploration. In this work, red blood cell membrane coating technique was used to camouflage inorganic BNNS, thus forming biomimetic RBC-membrane-coated BNNS (RBC-BNNS) drug delivery system. The functionalization of BNNS with RBC-membrane was characterized by transmission electron microscopy (TEM), particle size and zeta potential analysis. Besides, the influence of RBC-membrane modification to the drug loading capacity was also analyzed with doxorubicin as model drug. Then, the human cervical carcinoma cell line HeLa cells was selected as model cancer cells to investigate the biocompatibility of RBC-BNNS and the cellular uptake and antitumor effect of DOX@RBC-BNNS. This work may provide instructive reference for the design and construction of drug delivery system for cancer therapy.
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